Homatromide

Homatropine

Homatropine bromide

Systematic (IUPAC) name
(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
Identifiers
CAS number	80-49-9
ATC code	A02BX03 S01FA05
PubChem	CID 6646
DrugBank	APRD01017
ChemSpider	16498795
UNII	68JRS2HC1C
ChEMBL	CHEMBL1201235
Chemical data
Formula	C16H22BrNO3
Mol. mass	356.26 g/mol
SMILES	eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
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Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt. The latter, in addition to papaverine, is used as component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effects

Contraindications

References

Retrieved from : http://en.wikipedia.org/wiki/Homatropine